Single-domain antibodies for biomedical applications
نویسندگان
چکیده
منابع مشابه
Single-domain antibodies for biomedical applications.
Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding. This class of antibody derivatives comprises naturally occurring variable domains derived from camelids and sharks as well as engineered human variable or constant antibody domains of the heavy or l...
متن کاملEditorial: Single-Domain Antibodies—Biology, Engineering and Emerging Applications
Since the discovery of camelid heavy chain-only antibodies (HCAbs) in 1993 (1) and shark immunoglobulin new antigen receptors (IgNARs) in 1995 (2), and the subsequent recognition that the variable domains of these antibodies (VHHs and VNARs, respectively) function autonomously as single-domain antibodies (sdAbs), sdAbs have found many uses across diverse fields. Early work on naturally-occurrin...
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Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains. HCAbs fail to incorporate light (L) chains owing to the deletion of the first constant domain and a reshaped surface at the VHH side, which normally ...
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ژورنال
عنوان ژورنال: Immunopharmacology and Immunotoxicology
سال: 2015
ISSN: 0892-3973,1532-2513
DOI: 10.3109/08923973.2015.1102934